The scrutiny over Coke’s sweeteners began Wednesday, when President Donald Trump announced that Atlanta-based Coca-Cola Co. had agreed to switch to using cane sugar in the regular version of its beverage manufactured in the U.S.

Soft-drink makers’ potential shift from high-fructose corn syrup to real sugar could have deep implications not only for the beverage industry, but also the sugar cane and corn sectors in the U.S.

A possible move by Coca-Cola , and other beverage and food industries, to use cane sugar instead of corn syrup as a sweetener would be difficult and expensive to implement, while mostly negative for farmers in the United States.

A switch to cane sugar could result in an economic hit to Iowa, which is the largest producer of corn in the U.S.

Agricultural industry leaders fear a push away from corn syrup could disrupt production of the U.S.’s largest crop.