eLife3d
eLife appoints Timothy Behrens as Editor-in-Chief
As Editor-in-Chief, Behrens is responsible for the editorial direction and vision of the journal, providing leadership to ...
eLife3d
Interaction hierarchy among Cdv proteins drives recruitment to membrane necks
This valuable study investigates how the proteins of the Cdv division system in Metallosphaera sedula archaea sequentially interact with curved membranes in vitro, extending our understanding of this ...
eLife3d
Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen
In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.
eLife2d
Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria
Understanding bacterial growth mechanisms can potentially help uncover novel drug targets that are crucial for maintaining cellular viability, particularly for bacterial pathogens. In this important ...
eLife2d
Unbiased identification of cell identity in dense mixed neural cultures
Morphological profiling allows accurate identification of cell types in dense iPSC-derived cultures, allowing its use for quality control and differentiation monitoring.
eLife3d
Teichoic acids in the periplasm and cell envelope of Streptococcus pneumoniae
The bacterial cell wall is crucial to maintain viability. It has previously been suggested that Gram-positive bacteria have a periplasmic region between the cell membrane and peptidoglycan cell wall ...
eLife3d
Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments
This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...
eLife3d
Chromatin activity of IκBα mediates the exit from naïve pluripotency
This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...
eLife3d
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions in the membrane. Here, we elucidate the intricate ...
eLife5d
A New Role for RNA G-quadruplexes in Aging and Alzheimer’s Disease
The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.
eLife10d
Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes
This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...
eLife6d
Canonical neurodevelopmental trajectories of structural and functional manifolds
There is a planned Crossref maintenance outage between Tuesday, 14 January 6:00 to 11:00 UTC. This impacts access to BibTeX and RIS files.