Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

The rapid identification of respiratory virus outbreaks is needed to enable rational and effective public health interventions. We developed new quantitative approaches for simultaneous ...

Facilities operated by the US Department of Energy (DOE) are required to have extensive worker safety and health programs by regulation. We describe how Argonne National Laboratory (ANL) has ...

Reactions between skin oil and ozone are a substantial source of volatile organic compounds (VOCs) emitted from the human body, yet factors influencing these reactions and emissions have only recently ...

Biomolecular condensates exhibit distinct microenvironments that arise from interactions between proteins, RNA, and solutions. In aqueous solutions, these membraneless structures constantly encounter ...

Thermal safety is a key bottleneck in the development of high-energy-density batteries, primarily due to the high volatility and flammability of organic electrolytes. Efforts to enhance battery safety ...

MDM2 is a key negative regulator of the tumor suppressor p53 and an attractive target for cancer therapy. We report the discovery of MD-4251, the first orally efficacious MDM2 degrader developed using ...

Transferrin receptor 1 (TfR1) is a ubiquitously expressed receptor characterized by rapid internalization kinetics and efficient receptor recycling, making it an attractive target for drug delivery.

Understanding interfacial ion-transfer kinetics is central to advancing electrochemical processes associated with energy storage and catalysis. Here we investigate electrochemical proton-insertion ...

Hybrid organic–inorganic perovskites have garnered significant attention in optoelectronics due to their exceptional optical and electrical properties. Among them, low-dimensional chiral perovskites ...

Photoacoustic imaging (PAI), renowned for its high spatial resolution and deep tissue penetration, holds great promise for disease diagnosis and molecular detection. However, the performance of ...

The observation of increasing lithium-ion transference numbers upon increasing anion size has been frequently reported in the literature. While in dilute systems this can be explained by reduced ...